Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Isopropanol → 4-[3-[4-(6-Fluoro1,2-benzisoxazol-3-yl)-piperidinyl]-2-hydroxy-1-propoxy]phenyl methyl ether
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Isopropanol | HCID 3776 | — |
| 반응물 | 3-(4-Piperidyl)-6-fluoro-1,2-benzisoxazole | HCID 849421 | — |
| 반응물 | 2,3-Epoxypropyl4-methoxyphenyl ether | HCID 19964422 | — |
| 생성물 | 4-[3-[4-(6-Fluoro1,2-benzisoxazol-3-yl)-piperidinyl]-2-hydroxy-1-propoxy]phenyl methyl ether | HCID 18467257 | — |
반응 단계
A mixture of 4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidine (4.4 g, 20 mmol) and 2,3-epoxypropyl4-methoxyphenyl ether (3.7 g, 20.5 mmol) in isopropyl alcohol (80 ml) was heated to reflux for 2 hours. The mixture was cooled and the crystals were collected to yield 6.81 g (85%), m.p.=134°-135° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05646161 |
| 출처 데이터셋 | uspto-grants-1997_07 |
| ORD ID | ord-b5c7110c84bd41d2bec26d3f7d8971a6 |
| 출처 메모 | uspto-grants-1997_07 |