참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Trimethylsilyl cyanide | HCID 82115 | — |
| 반응물 | 4-[(5,6,7,8-Tetrahydro-8,8-dimethyl-5-oxonaphth-3-yl)ethynyl]benzoic acid | HCID 18314593 | — |
| 촉매 | Boron trifluoride etherate | HCID 8000 | — |
| 생성물 | 4-[(5-Cyano-7,8-dihydro-8,8-dimethylnaphth-3-yl)ethynyl]benzoic acid | HCID 23001771 | — |
반응 단계
To 76 mg (0.24 mmol) of 4-[(5,6,7,8-tetrahydro-8,8-dimethyl-5-oxonaphth-3-yl)ethynyl]benzoic acid (Compound 8) was added 0.06 ml (0.48 mmol) of cyanotrimethylsilane and 6 drops of boron trifluoride etherate. The resulting dark mixture was heated at 80° C for 45 minutes, cooled to room temperature and purified by flash chromatography (silica, 50% EtOAc-hexane) to yield the title compound as a yellow solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05648514 |
|---|
| 출처 데이터셋 | uspto-grants-1997_07 |
|---|
| ORD ID | ord-03a3bb5d7b4f4ec0af10439e9aa05936 |
|---|
| 출처 메모 | uspto-grants-1997_07 |
|---|
