참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Acetic Anhydride | HCID 7918 | — |
| 반응물 | 1-Bromopentane | HCID 8057 | — |
| 반응물 | 2-Pentanone, 5-chloro- | HCID 79993 | — |
| 반응물 | Magnesium | HCID 5462224 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | 1-Chloro-4-acetoxy-4-methylnonane | HCID 20386091 | — |
반응 단계
To the Grignard reagent prepared from 1-bromopentane (4.8 g., 0.04 mole) and magnesium (0.96 g., 0.04 mole) in ether is added 5-chloro-2-pentanone (6.0 g., 0.04 mole). The reaction mixture is stirred at 25° C. for 1 hour and then cooled to 15° C. Acetic anhydride (6 ml., excess) is added carefully and the solution is allowed to stand for 20 hours. Water is added, and the ether layer is separated, washed with brine, and dried over sodium sulfate. Distillation affords the title compound in 4.3 g. (46%) yield, b.p. 88° C. (0.1 mm.).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04150235 |
|---|
| 출처 데이터셋 | uspto-grants-1979_04 |
|---|
| ORD ID | ord-128778f48ccd4e9884777d39704485c0 |
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| 출처 메모 | uspto-grants-1979_04 |
|---|
