Dimethylformamide → HCID 178422953, 화합물

HRID 267505

반응식

HRID 267505 반응식
[CH3:1][C:2]1[N:11]=[C:10]2[C:5]([C:6](=[O:15])[C:7]([C:12](O)=O)=[CH:8][NH:9]2)=[CH:4][CH:3]=1.[NH2:16][C:17]1[NH:21][N:20]=[N:19][N:18]=1.CN(C)[CH:24]=[O:25]>>[CH3:1][C:2]1[N:11]=[C:10]2[C:5]([C:6](=[O:15])[C:7]([CH2:12][C:24]([NH:16][C:17]3[NH:21][N:20]=[N:19][N:18]=3)=[O:25])=[CH:8][NH:9]2)=[CH:4][CH:3]=1

참가 물질

4

반응물 3

HCID 6228DimethylformamideHCID 53736724-Hydroxy-7-methyl-1,8-naphthyridine-3-carboxylic acidHCID 178509299HCID 178509299, 화합물

생성물 1

HCID 178422953HCID 178422953, 화합물

실험 절차

1,4-Dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid (4 g) and N,N'-carbonyldiimidazole (3.5 g) in dimethylformamide (40 ml) were heated at 80° for 6 hours. 5-Amino-1H-tetrazole (2.5 g) was added and the mixture was stirred and heated at 80° for 1.5 hours. The solid was collected and dissolved in aqueous sodium hydroxide. The solution was acidified with glacial acetic acid and the solid was collected and dried. It had m.p. 344°-345.5°, (47%)

후처리

  1. temperatureheated at 80° for 1.5 hours
  2. customThe solid was collected
  3. dissolutiondissolved in aqueous sodium hydroxide
  4. customthe solid was collected
  5. customdried

출처 및 근거

ORD 기록
ord-d798cd99aa324fcf9bd1f12ba2b3a220
출처 데이터셋
uspto-grants-1976_03
특허 번호
US03943141

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