Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
alpha-(4-chlorophenyl)-alpha-(2-dimethylaminomethyl phenyl)-alpha-hydroxy-N-methyl-o-toluamide → 3-(4-Chlorophenyl)-3-(2-dimethylaminomethyl phenyl) phthalide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | alpha-(4-chlorophenyl)-alpha-(2-dimethylaminomethyl phenyl)-alpha-hydroxy-N-methyl-o-toluamide | HCID 21554039 | — |
| 용매 | 1,2-Dichlorobenzene | HCID 7239 | — |
| 생성물 | 3-(4-Chlorophenyl)-3-(2-dimethylaminomethyl phenyl) phthalide | HCID 54539385 | — |
반응 단계
A mixture of 40.8 g. (0.1 mole of α-(4-chlorophenyl)-α-(2-dimethylaminomethyl phenyl)-α-hydroxy-N-metyl-o-toluamide and 200 ml. o-dichlorobenzene is refluxed for 20 hours, cooled and the solvent is removed in vacuo. The residue is triturated with ether and the resulting solid is recrystallized from ether-methylene chloride (1:1) to give 3-(4-chlorophenyl)-3-(2-dimethylaminomethyl phenyl) phthalide; m.p. 138.5° - 140°C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US03944570 |
| 출처 데이터셋 | uspto-grants-1976_03 |
| ORD ID | ord-a442e4a183144b26823e3f24212e1708 |
| 출처 메모 | uspto-grants-1976_03 |