Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Phenylacetonitrile → Ethyl 3-cyano-3-phenylpyruvate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Phenylacetonitrile | HCID 8794 | — |
| 반응물 | Sodium ethoxide | HCID 2723922 | — |
| 반응물 | Ethanedioic acid, monoethyl ester | HCID 21943339 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | Ethyl 3-cyano-3-phenylpyruvate | HCID 22845 | — |
반응 단계
A mixture of 117.1 g. (1.0m.) of phenylacetonitrile and 326 ml. (2.4m.) of ethyl oxalate is added to an ethanol solution of sodium ethoxide (prepared by dissolving 23.8 g., 1.08m. of sodium in 500 ml. of absolute ethanol) and refluxed two hours. After cooling, diluting with 2500 ml. of water and extracting with ether, the solution is acidified with acetic acid. The solid is removed and washed with water to give ethyl 3-cyano-3-phenylpyruvate, m.p. 127°-129° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US03944571 |
| 출처 데이터셋 | uspto-grants-1976_03 |
| ORD ID | ord-5a583588cf9a4ecd87ac26e99fc1ed56 |
| 출처 메모 | uspto-grants-1976_03 |