참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 3-(2'-Methyl-2'-nitrobutyl)-indole | HCID 21552242 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 3-(2'-Amino-2'-methylbutyl)-indole | HCID 21552235 | 95.3% |
반응 단계
Reduction: A mixture of 90.0 g (388 mM) of the nitro intermediate and 9.0 g of palladium catalyst (5% on carbon) and 1000 ml of absolute ethanol was covered with hydrogen at a pressure of 25 atmospheres gauge in the autoclave whereupon it was heated to 70°C. and agitation was continued at this temperature for 7 hours. Filtration, evaporation in vacuo, recrystallisation from xylene and processing of the mother liquor yielded 74.7 g of 3-(2'-amino-2'-methylbutyl)-indole. (Yield: 95% of the theoretical).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US03947584 |
|---|
| 출처 데이터셋 | uspto-grants-1976_03 |
|---|
| ORD ID | ord-1967a7e4e7cb4c268178129f7030ca79 |
|---|
| 출처 메모 | uspto-grants-1976_03 |
|---|
