Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Amino-2-methyl-1,3-propanediol → 5-Bromo-6-chloro-N-(1,3-dihydroxy-2-methylpropan-2-yl)pyridine-3-sulfonamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Amino-2-methyl-1,3-propanediol | HCID 1531 | — |
| 반응물 | 5-Bromo-6-chloropyridine-3-sulfonyl chloride | HCID 2793626 | — |
| 생성물 | 5-Bromo-6-chloro-N-(1,3-dihydroxy-2-methylpropan-2-yl)pyridine-3-sulfonamide | HCID 86607992 | 83.4% |
반응 단계
Prepared by general procedure III from 3-bromo-2-chloropyridine-5-sulphonylchloride (580 mg, 2 mmol) and 2-amino-2-methyl-1,3-propanediol (231 mg, 2 mmol) to give 5-Bromo-6-chloro-pyridine-3-sulfonic acid (2-hydroxy-1-hydroxymethyl-1-methyl-ethyl)-amide (600 mg, 83%) as a yellow solid. MS (ISN) 357[(M−H)−], 359.0[(M+2−H)−], 361.0[(M+4−H)−].
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07446113B2 |
| 출처 데이터셋 | uspto-grants-2008_11 |
| ORD ID | ord-d0223da97e17441db149941e841a1899 |
| 출처 메모 | uspto-grants-2008_11 |