Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-[(4-Bromobenzene)sulfonyl]morpholine → 7-Difluoromethyl-3-[4-(morpholine-4-sulfonyl)-phenylethynyl]-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-[(4-Bromobenzene)sulfonyl]morpholine | HCID 253128 | — |
| 반응물 | 3-Ethynyl-7-difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine | HCID 86608034 | — |
| 생성물 | 7-Difluoromethyl-3-[4-(morpholine-4-sulfonyl)-phenylethynyl]-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine | HCID 11852936 | — |
반응 단계
The title compound was prepared from 7-Difluoromethyl-3-ethynyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine (example C.2) (340 mg, 1.0 mmol) and 4-(4-bromo-benzenesulfonyl)-morpholine (example B.26) (276 mg, 1.0 mmol) according to general procedure II. Obtained as a yellow solid (420 mg, 74%). MS (ISP) 563.4 [(M+H)+]; mp 227-228° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07446113B2 |
| 출처 데이터셋 | uspto-grants-2008_11 |
| ORD ID | ord-71a44de326a04258a55bad847311b686 |
| 출처 메모 | uspto-grants-2008_11 |