Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-(3-Phenylpropyl)piperidine → 1-(2,5-Difluoro-4-methoxyphenyl)-4-(3-phenylpropyl)piperidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-(3-Phenylpropyl)piperidine | HCID 87678 | — |
| 반응물 | 4-Bromo-1-methoxy-2-methylbenzene | HCID 608315 | — |
| 반응물 | 4-Bromo-2,5-difluoroanisole | HCID 2724983 | — |
| 생성물 | 1-(2,5-Difluoro-4-methoxyphenyl)-4-(3-phenylpropyl)piperidine | HCID 23111506 | 33.7% |
반응 단계
Production Example 9 was repeated except that 5-bromo-2-methoxytoluene and 1-(2-phenethyl)piperazine were replaced with 4-bromo-2,5-difluoroanisole (446 mg) and 4-(3-phenylpropyl)-piperidine (1.220 g), respectively. The resulting crude product was purified on silica gel column chromatography (eluent, hexane: ethyl acetate=8:1) to provide 1-(2,5-difluoro-4-methoxyphenyl)-4-(3-phenylpropyl)piperidine (233 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07449466B2 |
| 출처 데이터셋 | uspto-grants-2008_11 |
| ORD ID | ord-d6123d46385f408a9055741a7d9c4e2a |
| 출처 메모 | uspto-grants-2008_11 |