참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Phosgene | HCID 6371 | — |
| 반응물 | 1-(Piperazin-1-yl)propan-1-one | HCID 3844375 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 4-Propanoylpiperazine-1-carbonyl chloride | HCID 14369520 | 98.8% |
반응 단계
A solution of phosgene (45.0 g.) in anhydrous toluene (500 cm3) and 1-propionylpiperazine (129.0 g.) are added simultaneously to anhydrous toluene (500 cm3), while the temperature is maintained at about -5° C. 1-Chlorocarbonyl-4-propionylpiperazine (92.0 g.), m.p. about 45° C., is thus obtained. After one hour's stirring at 2° C., the 1-propionylpiperazine hydrochloride formed is separated by filtration and, after evaporation of the filtrate under reduced pressure (20 mm.Hg) 1-chlorocarbonyl-4-propionyl-piperazine is obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04220646 |
|---|
| 출처 데이터셋 | uspto-grants-1980_09 |
|---|
| ORD ID | ord-454a4d1d047944559f6b3e3e7e08114b |
|---|
| 출처 메모 | uspto-grants-1980_09 |
|---|
