Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Bicarbonate → Ethyl N-(tert-butoxycarbonyl)-L-tyrosinate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | Tyrosine ethyl ester hydrochloride | HCID 2724939 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 용매 | Water methylene chloride | HCID 21908982 | — |
| 생성물 | Ethyl N-(tert-butoxycarbonyl)-L-tyrosinate | HCID 11077750 | 180.9% |
반응 단계
To a mixture of L-tyrosine ethyl ester hydrochloride (55.08 g) and NaHCO3 (22.52 g) in CH2Cl2/H2O (280 ml/280 ml) was added di-tert-butyl bicarbonate (56.82 g) portionwise. The mixture was stirred for 2 hours at room temperature and diluted with AcOEt. The organic layer was washed with H2O, dried (Na2SO4) and evaporated. The residue was recrystallized from a mixture of diethyl ether and hexane to yield N-(tert-butoxycarbonyl)-L-tyrosine ethyl ester (62.71 g). mp. 87-88° C.; MS (APCI) m/z 327 (M+NH4), 310 (M+H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07456217B2 |
| 출처 데이터셋 | uspto-grants-2008_11 |
| ORD ID | ord-aa5238431014468aaa807ee697aa9a53 |
| 출처 메모 | uspto-grants-2008_11 |