참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 2-Ethyl-6-methylaniline | HCID 32485 | — |
| 반응물 | 4-(Chloromethyl)-1,3-thiazole | HCID 2763290 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | N-(thiazol-4-yl)methyl-2-ethyl-6-methylaniline | HCID 20534534 | 39.7% |
반응 단계
In 200 ml dry dimethylformamide was added 10.2 g 4-chloromethylthiazole, 10.26 g 2-ethyl-6-methylaniline and 10.54 g of potassium carbonate. The mixture was stirred at 100° C. for 3 days and filtered. The filtrate was stripped, dissolved in methylene chloride, washed with water, dried and stripped again. The crude product was chromatographed with methylene chloride through a 200-g silica-gel column to give 7 g of product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04221584 |
|---|
| 출처 데이터셋 | uspto-grants-1980_09 |
|---|
| ORD ID | ord-b9e27a171eb14d4e9634988a95ba4bfe |
|---|
| 출처 메모 | uspto-grants-1980_09 |
|---|
