Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
tert-Butyl hydroperoxide → (3S,8R,9S,10R,13S,14S,17S)-10,13-Dimethyl-7-oxo-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,17-diyl diacetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | tert-Butyl hydroperoxide | HCID 6410 | — |
| 반응물 | Androstenediol diacetate | HCID 102205 | — |
| 촉매 | Chromium hexacarbonyl | HCID 25589 | — |
| 생성물 | (3S,8R,9S,10R,13S,14S,17S)-10,13-Dimethyl-7-oxo-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,17-diyl diacetate | HCID 9886600 | — |
반응 단계
A second method of preparing βAET has been developed which also used 3β,17β diacetoxyandrost-5-ene as a starting material as before. This compound was oxidized with t-butylhydroperoxide in the presence of chromium hexacarbonyl (Cr(CO)6) to form 3β,17β-diacetoxyandrost-5-en-7-one as described by Pearson [Pearson, et al., J. Chem Soc. Perkin Trans. I, 267 (1985)]. The enone formed then was reduced with triisobutylaluminum (TIBA) to give the acetylated 7β-hydroxy (I) product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05387583 |
| 출처 데이터셋 | uspto-grants-1995_02 |
| ORD ID | ord-e3965bd07bf44d599ea9efd61d5ff839 |
| 출처 메모 | uspto-grants-1995_02 |