Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Chlorobenzenesulfonyl chloride → 3-Cyanomethyl-1-(4-chlorophenylsulfonyl)pyrrolidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Chlorobenzenesulfonyl chloride | HCID 7398 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 2-(Pyrrolidin-3-yl)acetonitrile hydrochloride | HCID 20078139 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 생성물 | 3-Cyanomethyl-1-(4-chlorophenylsulfonyl)pyrrolidine | HCID 20078166 | 101.1% |
반응 단계
Acylation, in chloroform, of 36.6 g (0.25 mol) of 3-cyanomethylpyrrolidine hydrochloride with 52.7 g (0.25 mol) of para-chlorophenylsulfonic acid chloride, in the presence of 50.5 g (0.5 mol) of triethylamine makes it possible to obtain 72 g of a solid which is purified by chromatography on silica, Merck 70-230 mesh, using as eluent a dichloromethane/methanol mixture (99/1 v/v).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05387591 |
| 출처 데이터셋 | uspto-grants-1995_02 |
| ORD ID | ord-f57e2c7f26ac4a6085f3586e6f76abbd |
| 출처 메모 | uspto-grants-1995_02 |