Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → 2-[(4-Chlorophenyl)methyl]azepane
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Sodium borohydride | HCID 4311764 | — |
| 반응물 | 2-(4-chlorobenzyl)-4,5,6,7-tetrahydro-3H-azepine | HCID 23342815 | — |
| 용매 | Hydrochloric Acid | HCID 313 | — |
| 생성물 | 2-[(4-Chlorophenyl)methyl]azepane | HCID 3933809 | — |
반응 단계
Dissolve the thus-obtained 2-(4-chlorobenzyl)-4,5,6,7-tetrahydro-3H-azepin in diluted hydrochloric acid (pH~5) and mix it with 200 ml of methyl alcohol. Add 7 g of sodium borohydride in small portions within 20 minutes, keeping the pH-value constant by occasional addition of hydrochloric acid. Stir for 1 hour, render alkaline with caustic soda solution and extract with dichlormethane. Dry the organic phase over sodium sulphate, concentrate and distil to obtain 58 g of the title compound with a BP of 93° at 0.1 mm Hg.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04221788 |
| 출처 데이터셋 | uspto-grants-1980_09 |
| ORD ID | ord-21323675bc27472ba43cbb65f44ca2dc |
| 출처 메모 | uspto-grants-1980_09 |