Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Aluminium lithium hydride → 2-[(4-Chlorophenyl)methyl]azepane
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Aluminium lithium hydride | HCID 21226445 | — |
| 반응물 | 7-(4-Chlorobenzyl)perhydroazepin-2-one | HCID 23342851 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 2-[(4-Chlorophenyl)methyl]azepane | HCID 3933809 | 68.3% |
반응 단계
Add 0.5 g of lithium aluminum hydride to a solution of 2.8 g 7-(4-chlorobenzyl)-perhydroazepin -2-one in 30 ml of tetrahydrofurane. Boil the mixture under reflux for 16 hours, cool it and then carefully treat it with ice-water. After extraction with diethyl ether, dry the extract over sodium sulfate concentrate the oily residue and distill in a vacuum to obtain 1.8 g of the title compound with a BP of 90° to 92° at 0.05 mm Hg.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04221788 |
| 출처 데이터셋 | uspto-grants-1980_09 |
| ORD ID | ord-32cc92d9280349b984ea48408cc67dba |
| 출처 메모 | uspto-grants-1980_09 |