Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Cysteamine Hydrochloride → 2-(((5-Methyl-1H-imidazol-4-yl)methyl)thio)ethylamine dihydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Cysteamine Hydrochloride | HCID 9082 | — |
| 반응물 | 4-Methylimidazol-5-ylmethanolhydrochloride | HCID 3084707 | — |
| 용매 | Hydrochloric Acid | HCID 313 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | 2-(((5-Methyl-1H-imidazol-4-yl)methyl)thio)ethylamine dihydrochloride | HCID 3015999 | 164.7% |
반응 단계
A solution of 4-hydroxymethyl-5-methylimidazole hydrochloride (30.0 g.) and cysteamine hydrochloride (23.0 g.) in concentrated aqueous hydrochloric acid (450 ml.) was heated under reflux for 17 hours. Concentration followed by re-evaporation with water afforded a residue which was dissolved in isopropyl alcohol, concentrated to low bulk and cooled to afford 4-methyl-5-[(2-aminoethyl)thiomethyl]-imidazole dihydrochloride (40.6 g.), m.p. 185°-191°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04221802 |
| 출처 데이터셋 | uspto-grants-1980_09 |
| ORD ID | ord-9d4a886ceb724adbb862d5e6bfc3186b |
| 출처 메모 | uspto-grants-1980_09 |