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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 2781생성일: 2026년 10월 24일

5-Pyridin-3-yl-thiophene-2-sulfonyl chloride → 5-Pyridin-3-yl-thiophene-2-sulfonic acid [1-(5-cyano-2-fluoro-benzyl)-2-oxo-pyrrolidin-3-(S)-yl]-amide

https://huagongshe.com/ko/reaction/2781

반응식

참여 물질

역할이름HCID투입량
반응물5-Pyridin-3-yl-thiophene-2-sulfonyl chlorideHCID 10658976—
반응물3-(S)-[(3-amino-2-oxo-pyrrolidin-1-yl)-methyl]-4-fluoro-benzonitrile hydrochlorideHCID 22883627—
생성물5-Pyridin-3-yl-thiophene-2-sulfonic acid [1-(5-cyano-2-fluoro-benzyl)-2-oxo-pyrrolidin-3-(S)-yl]-amideHCID 10742450—

반응 단계

The title compound is prepared from 3-(S)-[(3-amino-2-oxo-pyrrolidin-1-yl)-methyl]-4-fluoro-benzonitrile hydrochloride as described in EXAMPLE 17, Part G substituting 5-pyridin-3-yl-thiophene-2-sulfonyl chloride in place of 4,6-dichlorobenzo[b]thiophene-2-sulfonyl chloride. The crude product is triturated with Et2O to give the title compound as a white solid

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US05731315
출처 데이터셋uspto-grants-1998_03
ORD IDord-806352f5d1f24257a0c79e1cedfd6e4a
출처 메모uspto-grants-1998_03