Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Formamide → 7-Fluoroquinazolin-4(3H)-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Formamide | HCID 713 | — |
| 반응물 | 4-Fluoroanthranilic acid | HCID 2724967 | — |
| 반응물 | Dichloromethane methanol | HCID 21226129 | — |
| 생성물 | 7-Fluoroquinazolin-4(3H)-one | HCID 135398496 | 82% |
반응 단계
A solution of 2-amino-4-fluorobenzoic acid (3 g, 19.3 mmol) in formamide (30 ml) was heated at 150° C. for 6 hours. The reaction mixture was poured onto ice/water 1/1 (250 ml). The precipitated solid was collected by filtration, washed with water and dried to give 7-fluoro-3,4-dihydroquinazolin-4-one (2.6 g, 82%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06362336B1 |
| 출처 데이터셋 | uspto-grants-2002_03 |
| ORD ID | ord-e76a6d410ada441f9c6dab92f41e4816 |
| 출처 메모 | uspto-grants-2002_03 |