참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Dimethyl Sulfate | HCID 6497 | — |
| 반응물 | 2-Furancarboxylic acid | HCID 6919 | — |
| 반응물 | Anisole | HCID 7519 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 용매 | Acetone | HCID 180 | — |
| 용매 | Potassium Hydroxide | HCID 14797 | — |
| 용매 | Sodium | HCID 5360545 | — |
| 생성물 | Dimethyl Sulfate | HCID 6497 | — |
| 생성물 | 2-Hydroxy-1-naphthoic acid | HCID 16790 | — |
| 생성물 | Methyl 2-methoxy-1-naphthoate | HCID 604022 | — |
반응 단계
This methyl ester was previously made by fusion of anisole and 2-furoic acid followed by esterification of the acid intermediate, J. Amer. Chem. Soc., Vol. 69, 2261 (1947). Methyl esters of methoxy carboxylic acids were prepared by methylation of aromatic hydroxy carboxylic acids with dimethyl sulfate in the presence of potassium carbonate as base, using acetone as the solvent, Houben-Weyl, Methoden der Organischen Chemie., Vol. 8, 542-3 (1952). Methylation of 2-hydroxy-1-naphthoic acid with dimethyl sulfate in aqueous sodium or potassium hydroxide produced mainly methyl-2-methoxy-1-naphthalenecarboxylate, Chemische Berichte, Vol. 37, 3658-61 (1904). In aqueous solutions, at pH 4-6.5, methylation of hydroxy napthoic acids with dimethyl sulfate produced the methyl esters of the hydroxy naphthoic acids.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04590290 |
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| 출처 데이터셋 | uspto-grants-1986_05 |
|---|
| ORD ID | ord-c324ab068a684be1923eb42b45f5f752 |
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| 출처 메모 | uspto-grants-1986_05 |
|---|
