Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Methyl-5-(2-hydroxyethyl)thiazole → HCID 18936369, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Methyl-5-(2-hydroxyethyl)thiazole | HCID 1136 | — |
| 반응물 | 1-(Thiophen-3-yl)ethanone | HCID 15116 | — |
| 반응물 | Butyllithium | HCID 178418339 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | HCID 18936369 | HCID 18936369 | — |
반응 단계
n-Butyllithium (2.5M solution in hexanes, 75 mmoles) was added to a stirred solution of 5-(2-hydroxyethyl)-4-methylthiazole (35 mmoles) in dry tetrahydrofuran (80 ml) at -70° C. under an atmosphere of dry nitrogen. After 30 minutes, 3-acetylthiophene (38 mmoles) in dry tetrahydrofuran (10 ml) was added dropwise. After 1 hour the mixture was allowed to warm to room temperature and was then stirred overnight. The normal work-up followed by column chromatography then gave the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05731335 |
| 출처 데이터셋 | uspto-grants-1998_03 |
| ORD ID | ord-5a5eb6ad04954fd4aa68e9d330119b48 |
| 출처 메모 | uspto-grants-1998_03 |