Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl 3-(5-chloro-2-methylphenyl)-3-oxopropanoate → Acetamidine monohydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl 3-(5-chloro-2-methylphenyl)-3-oxopropanoate | HCID 58063452 | — |
| 반응물 | 4-Chloro-6-(5-chloro-2-methoxyphenyl)-2-methylpyrimidine | HCID 65645326 | — |
| 생성물 | Acetamidine monohydrochloride | HCID 67170 | 11% |
| 생성물 | 4-Chloro-6-(5-chloro-2-methyl-phenyl)-2-methyl-pyrimidine | HCID 86004323 | — |
반응 단계
4-Chloro-6-(5-chloro-2-methyl-phenyl)-2-methyl-pyrimidine was prepared according to the method described in Example 38 for the synthesis of 4-chloro-6-(5-chloro-2-methoxy-phenyl)-2-methyl-pyrimidine in two steps using 3-(5-chloro-2-methyl-phenyl)-3-oxopropionic acid ethyl ester and acetamidine hydrochloride (11% yield). 1H NMR (DMSO-d6) δ 2.36 (s, 3H, CH3), 2.68 (s, 3H, CH3), 7.40 (d, 1H, J=8.3 Hz, Ar), 7.49 (dd, 1H, J=8.3 Hz, J=2.3 Hz, Ar), 7.57 (d, 1H, J=2.3 Hz, Ar), 7.79 (s, 1H, Ar).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07419984B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-bae5914d1f5341669c054fa5645d9205 |
| 출처 메모 | uspto-grants-2008_09 |