Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 2-Chloro-1-[4-(trifluoromethyl)-3-pyridinyl]ethanone hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Chlorosuccinimide | HCID 31398 | — |
| 반응물 | Methyl 4-(trifluoromethyl)nicotinate | HCID 2775680 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | 2-Chloro-1-[4-(trifluoromethyl)-3-pyridinyl]ethanone hydrochloride | HCID 21864939 | 49% |
반응 단계
In a 100 mL flask was placed 1.84 g (9.7 mmol, 1 eq) of methyl 4-trifluoromethylnicotinate in 25 mL of 1 M HCl in CH3COOH. To this was then added 1.3 g of NCS (9.7 mmol, 1 eq) and the reaction allowed to stir overnight (18 h). The mixture was then transferred to a 500 mL Erlenmeyer flask and to this was added 300 mL of 2 M HCl in Et2O with stirring. This resulted in a white precipitate which was then filtered to provide 1.2 g (49%) of the desired 2-chloro-1-[4-(trifluoromethyl)-3-pyridinyl]ethanone hydrochloride as a white solid. 1H-NMR (DMSO-d6) δ 9.21 (s, 1H), 9.02 (d, 1H), 7.94 (d, 1H), 5.19 (s, 2H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07420066B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-bc486d40f494434eb4c1162bfa92226a |
| 출처 메모 | uspto-grants-2008_09 |