Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 29463생성일: 2026년 10월 24일
Potassium Carbonate → 2-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxymethyl]-benzofuran
https://huagongshe.com/ko/reaction/29463
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenol | HCID 2734624 | — |
| 반응물 | 2-(Bromomethyl)-1-benzofuran | HCID 12326316 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 2-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxymethyl]-benzofuran | HCID 67109971 | 63% |
반응 단계
To 2-bromomethyl-benzofuran (1.5 g, 7.1 mmol, 1 eq.), 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenol (1.56 g, 7.1 mmol, 1 eq.), potassium carbonate (1.96 g, 14.2 mmol, 2 eq.), and acetonitrile (50 mL) were added under argon and the reaction was heated at 70° C. for 16 hours. After work-up and flash column chromatography, 2-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxymethyl]-benzofuran was obtained in 63% yield. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.3 (s, 12 H) 5.3 (s, 2 H) 7.1 (m, 3 H) 7.3 (m, 1 H) 7.3 (m, 1 H) 7.6 (m, 4 H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07420001B2 |
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| 출처 데이터셋 | uspto-grants-2008_09 |
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| ORD ID | ord-57772b474b8d460c9ff0aabdfa445600 |
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| 출처 메모 | uspto-grants-2008_09 |
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