Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-(4-Aminopiperidin-1-yl)ethan-1-one → 1-{4-[6-Amino-5-(5-fluoro-2-methoxy-4-methyl-benzoyl)-pyridin-2-ylamino]-piperidin-1-yl}-ethanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-(4-Aminopiperidin-1-yl)ethan-1-one | HCID 4962477 | — |
| 반응물 | (2-Amino-6-chloro-pyridin-3-yl)-(5-fluoro-2-methoxy-4-methyl-phenyl)-methanone | HCID 58590831 | — |
| 생성물 | 1-{4-[6-Amino-5-(5-fluoro-2-methoxy-4-methyl-benzoyl)-pyridin-2-ylamino]-piperidin-1-yl}-ethanone | HCID 58590834 | — |
반응 단계
The title compound was prepared from (2-Amino-6-chloro-pyridin-3-yl)-(5-fluoro-2-methoxy-4-methyl-phenyl)-methanone (Example 43) and 1-(4-amino-piperidin-1-yl)-ethanone (prepared as described in D. Manefti et al, Biorg. Med. Chem. Lett., 13 (2003), 2303-2306) using the procedure described in Step B. Example 6. HRMS, observed: 401.1084, Calcd for (M+H)+: 401.1084.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07423051B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-dc408dbe1e004e01b4e7c5f362a58f9d |
| 출처 메모 | uspto-grants-2008_09 |