Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
[1-(Methylsulfonyl)piperidin-4-yl]amine trifluoroacetate → [2-Amino-6-(1-methanesulfonyl-piperidin-4-ylamino)-pyridin-3-yl]-(4-chloro-5-fluoro-2-methoxy-phenyl)-methanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | [1-(Methylsulfonyl)piperidin-4-yl]amine trifluoroacetate | HCID 11975076 | — |
| 반응물 | (2-Amino-6-chloro-pyridin-3-yl)-(4-chloro-5-fluoro-2-methoxy-phenyl)-methanone | HCID 58590823 | — |
| 생성물 | [2-Amino-6-(1-methanesulfonyl-piperidin-4-ylamino)-pyridin-3-yl]-(4-chloro-5-fluoro-2-methoxy-phenyl)-methanone | HCID 11705192 | — |
반응 단계
The title compound was prepared from (2-Amino-6-chloro-pyridin-3-yl)-(4-chloro-5-fluoro-2-methoxy-phenyl)-methanone (Example 47) and 1-methanesulfonyl-piperidin-4-ylamine (Step A, Example 6) using the procedure described in Step B. Example 6. HRMS, observed: 457.1106, Calcd for (M+H)+: 457.1107. Ki for cdk4=0.008 μM, cdk1=0.154 μM, cdk2=0.039 μM, and IC50 for HCT116 cell line=3.0 μM.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07423051B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-8be0577ea87f4689af3358b7a02cb424 |
| 출처 메모 | uspto-grants-2008_09 |