Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Phenylhydrazine → 2-amino-benzoic acid N'-(2-fluoro-phenyl)-hydrazide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Phenylhydrazine | HCID 7516 | — |
| 반응물 | Isatoic Anhydride | HCID 8359 | — |
| 반응물 | 2-Hydrazinopyridine | HCID 78645 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 2-Fluorophenylhydrazine hydrochloride | HCID 423844 | — |
| 용매 | Ethanol | HCID 702 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 용매 | Triethylamine | HCID 8471 | — |
| 생성물 | 2-amino-benzoic acid N'-(2-fluoro-phenyl)-hydrazide | HCID 68533247 | — |
반응 단계
A phenylhydrazine b (e.g., 2-fluorophenylhydrazine) or pyridinylhydrazine (e.g., 2-hydrazinopyridine) that has been treated with or without a base such as N,N-diisopropylethylamine or triethylamine in a suitable solvent (e.g., ethanol or tetrahydrofuran (THF)) is reacted with the anhydride a (e.g., isatoic anhydride) to give the hydrazide c (e.g., 2-amino-benzoic acid N′-(2-fluoro-phenyl)-hydrazide). c is then acidified and reacted with sodium nitrite, followed by ethanol to generate the indazole d (e.g., 1-(2-fluoro-phenyl)-1H-indazol-3-ol).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07423054B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-0906ba17b99a4bdba381cccc93999baa |
| 출처 메모 | uspto-grants-2008_09 |