Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-(tert-Butoxycarbonyl)-4-(methanesulfonyloxy)piperidine → 4-[4-Fluoro-1-(2-fluoro-phenyl)-1H-indazol-3-yloxy]-piperidine-1-carboxylic acid tert-butyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-(tert-Butoxycarbonyl)-4-(methanesulfonyloxy)piperidine | HCID 4184869 | — |
| 반응물 | BEMP resin | HCID 16216994 | — |
| 반응물 | 4-[1-(4-chloro-phenyl)-1H-indazol-3-yloxy]-piperidine-1-carboxylic acid tert-butyl ester | HCID 68530176 | — |
| 반응물 | HCID 178518865 | HCID 178518865 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 4-[4-Fluoro-1-(2-fluoro-phenyl)-1H-indazol-3-yloxy]-piperidine-1-carboxylic acid tert-butyl ester | HCID 68532836 | 51% |
반응 단계
4-[4-Fluoro-1-(2-fluoro-phenyl)-1H-indazol-3-yloxy]-piperidine-1-carboxylic acid tert-butyl ester (Intermediate 46) was prepared as described above for Intermediate 42 using Intermediate 45 (300 mg, 1.218 mmol), PS-BEMP resin (1.108 g) and 4-methanesulfonyloxy-piperidine-1-carboxylic acid tert-butyl ester (Intermediate 2) (374 mg, 1.34 mmol) in DMF (10 ml) to afford 265 mg (51%) of Intermediate 46 as a yellow oil. MS (M+1)=430.2.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07423054B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-150fdb8a77df4999909115a7edd9ba62 |
| 출처 메모 | uspto-grants-2008_09 |