Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic Acid → Diethyl 2-[(3-formylphenyl)methylene]propane-1,3-dioate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | Piperidine | HCID 8082 | — |
| 반응물 | Isophthalaldehyde | HCID 34777 | — |
| 반응물 | 2,2-Diethylpropanedioate | HCID 6951563 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | Diethyl 2-[(3-formylphenyl)methylene]propane-1,3-dioate | HCID 59789754 | — |
반응 단계
Benzene 1,3 dicarbaldehyde (1 eq) is dissolved in toluene, and diethylmalonate (1 eq) is added, followed by piperidine (0.1 eq) and AcOH (0.1 eq). The flask is equipped with a Dean Stark trap and the reaction mixture is refluxed overnight. The reaction mixture is cooled down to room temperature, washed with water, 2% aq HCl, sat. aq NaHCO3, brine, and dried. The solvent is evaporated under reduced pressure and the product 32 is isolated by column chromatography on silicagel.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07423148B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-fd79de5b16c441b29e7acf5015ddc480 |
| 출처 메모 | uspto-grants-2008_09 |