Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,2-Dichloroethane → 1-[(5-Hydroxy-2-pyridinyl)carbonyl]-piperidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,2-Dichloroethane | HCID 11 | — |
| 반응물 | 4-Methylmorpholine | HCID 7972 | — |
| 반응물 | Piperidine | HCID 8082 | — |
| 반응물 | 1-Hydroxybenzotriazole | HCID 75771 | — |
| 반응물 | 5-Hydroxypyridine-2-carboxylic acid | HCID 268740 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | Ammonia | HCID 222 | 5% |
| 생성물 | 1-[(5-Hydroxy-2-pyridinyl)carbonyl]-piperidine | HCID 44515454 | 90% |
반응 단계
To a solution of 5-hydroxy-2-pyridine carboxylic acid (2.00 g, 14.0 mmol) and piperidine (1.5 mL, 15 mmol) in DCM (150 mL) was added HOBt (2.80 g, 21.0 mmol), EDC (4.00 g, 21.0 mmol), and N-methyl morpholine (8.5 mL, 84 mmol). After 18 h the reaction mixture was concentrated. Chromatography of the residue (SiO2; 5-10% 2 M NH3 in MeOH/DCM) gave the title compound as a solid (1.30 g, 43%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07423147B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-985f1f5d40da4132a25e0a2f3b49fa42 |
| 출처 메모 | uspto-grants-2008_09 |