Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → N-(3-{[4-(difluoromethoxy)phenyl]ethynyl}phenyl)ethanesulfonamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | Ethanesulfonyl chloride | HCID 11667 | — |
| 반응물 | 3-{[4-(Difluoromethoxy)phenyl]ethynyl}aniline | HCID 57435864 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | N-(3-{[4-(difluoromethoxy)phenyl]ethynyl}phenyl)ethanesulfonamide | HCID 59790328 | 91.4% |
반응 단계
A cold (0° C.) solution of 3-{[4-(difluoromethoxy)phenyl]ethynyl}aniline (0.5 g, 1.93 mmol) and pyridine (0.31 mL, 3.80 mmol) in CH2Cl2 was treated dropwise with ethylsulfonyl chloride (0.27 mL, 2.89 mmol). The mixture was stirred for 5 hours, poured into water and extracted with EtOAc/ethyl ether 1/1. The organic extracts were combined, dried over MgSO4 and concentrated in vacuo. Purification of the resultant residue on silica gel (Biotage) using hexanes/EtOAc (3/1) as the eluting solvent gave N-(3-{[4-(difluoromethoxy)phenyl]ethynyl}phenyl)ethanesulfonamide as a yellow oil (0.62 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07423158B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-a9064075b6f744c19024d33c4e103b56 |
| 출처 메모 | uspto-grants-2008_09 |