Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → N-[4-({2-[(3-isopropylphenyl)amino]-1,3-benzothiazol-5-yl}oxy)pyridin-2-yl]acetamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Potassium bis(trimethylsilyl)amide | HCID 3251421 | — |
| 반응물 | N-(4-Chloropyridin-2-yl)acetamide | HCID 22832129 | — |
| 반응물 | 2-(3-Isopropylphenylamino)benzo[d]thiazol-5-ol | HCID 86045337 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | N-[4-({2-[(3-isopropylphenyl)amino]-1,3-benzothiazol-5-yl}oxy)pyridin-2-yl]acetamide | HCID 59790209 | — |
반응 단계
The mixture containing 2-(3-isopropylphenylamino)benzo[d]thiazol-5-ol (1 eq), N-(4-chloropyridin-2-yl)acetamide (1.4 eq), potassium bis(trimethylsilyl)amide (4 eq) and potassium carbonate (1.2 eq) in dimethylformamide was subjected to the microwave at 200° C. for 15 minutes. The reaction was then partitioned between ethyl acetate and water. The organic layer was separated, washed with brine, dried over sodium sulfate and concentrated to give the crude product. Purification on HPLC to yield N-[4-({2-[(3-isopropylphenyl)amino]-1,3-benzothiazol-5-yl}oxy)pyridin-2-yl]acetamide. HPLC=4.87 min; MS: MH+=419.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07423150B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-716d0c889d634a7986a80df916a44b18 |
| 출처 메모 | uspto-grants-2008_09 |