Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylborane → 2-(2-Fluoro-5-nitrophenyl)-2-methylpent-4-enal
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylborane | HCID 7357 | — |
| 반응물 | Allyl Alcohol | HCID 7858 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Triphenylphosphine | HCID 11776 | — |
| 반응물 | Lithium Chloride | HCID 433294 | — |
| 반응물 | 2-(2-Fluoro-5-nitrophenyl)propanal | HCID 86600438 | — |
| 촉매 | palladium(II) acetate | HCID 167845 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 용매 | Sodium Bicarbonate | HCID 516892 | — |
| 생성물 | 2-(2-Fluoro-5-nitrophenyl)-2-methylpent-4-enal | HCID 86600439 | — |
반응 단계
To a solution of palladium acetate (0.1 eq), triphenylphosphine (0.2 eq), lithium chloride (1.0 eq) in THF were sequentially added 2-(2-fluoro-5-nitrophenyl) propanal (1.1 eq) in THF, allyl alcohol (1.0 eq), triethylamine (1.2 eq) and triethylborane (2.4 eq) under nitrogen at room temperature. Solution was allowed to stir for 2 h. Mixture was diluted with saturated solution of sodium bicarbonate, extracted with ethyl acetate. Organics were washed with brine, dried with sodium sulfate and concentrated. Crude product was purified using flash chromatography (85% Hex: 15% EtoAc) on silica to afford 2-(2-fluoro-5-nitrophenyl)-2-methylpent-4-enal.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07423150B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-c0ef632ba96748608141c61764770d25 |
| 출처 메모 | uspto-grants-2008_09 |