Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
O-(Trimethylsilyl)hydroxylamine → 2-(4-Hydroxyamino-5-oxazol-5-yl-pyrrolo[2,3-d]pyrimidin-7-yl)-5-hydroxymethyl-3-methyl-tetrahydro-furan-3,4-diol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | O-(Trimethylsilyl)hydroxylamine | HCID 2734666 | — |
| 반응물 | 2-(4-Chloro-5-oxazol-5-yl-pyrrolo[2,3-d]pyrimidin-7-yl)-5-hydroxymethyl-3-methyl-tetrahydro-furan-3,4-diol | HCID 86623589 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 2-(4-Hydroxyamino-5-oxazol-5-yl-pyrrolo[2,3-d]pyrimidin-7-yl)-5-hydroxymethyl-3-methyl-tetrahydro-furan-3,4-diol | HCID 72562986 | — |
반응 단계
The compound from Step 2 is suspended in dry ethanol and O-trimethylsilyl hydroxylamine (10 eq.) is added. The mixture is refluxed for 2 h, evaporated and the crude mixture purified by RP HPLC on a Phenominex column (250×20 mm) using a gradient of acetonitrile in water from 0 to 30% over 30 minutes at 10 mL/minute to yield the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07425547B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-d9827e1b6c9b4e9983e0a8ae85e58b4c |
| 출처 메모 | uspto-grants-2008_09 |