Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Chloro-3,5-dinitrobenzotrifluoride → 2,6-Dinitro-1-(2-phenylchroman-6-yloxy)-4-trifluoromethylbenzene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Chloro-3,5-dinitrobenzotrifluoride | HCID 9809 | — |
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | 2-Nitro-1-(2-phenylchroman-6-yloxy)-benzene | HCID 17978475 | — |
| 반응물 | 2-Phenylchroman-6-ol | HCID 21287538 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 생성물 | 2,6-Dinitro-1-(2-phenylchroman-6-yloxy)-4-trifluoromethylbenzene | HCID 17978580 | — |
반응 단계
2,6-Dinitro-1-(2-phenylchroman-6-yloxy)-4-trifluoromethylbenzene was prepared as described for 2-nitro-1-(2-phenylchroman-6-yloxy)-benzene in Example 29(a) except that 6-hydroxyflavane (0.453 g) was used in 10 ml of dry DMSO under nitrogen. Also KI (0.498 g) and KOH (0.224 g) and 4-chloro-3,5-dinitro benzotrifluoride (0.541 mg) were added in similar manner. 1H-NMR (400 MHz; d6-DMSO): δ 8.87 (s, 2H), 7.46-7.29 (m, 5H), 6.89-6.75 (m, 4H), 5.09 (dd, 1H, J=10.3 Hz, J=2.1 Hz), 2.98-2.85 (m, 1H), 2.75-2.62 (m, 1H), 2.19-2.08 (m, 1H), 2.03-1.88 (m, 1H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07425568B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-b57e550b989e402ebe3728bbf7c47b04 |
| 출처 메모 | uspto-grants-2008_09 |