Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-(Dimethylamino)ethanol → 6-(2-Dimethylaminoethoxy)-1-tetralone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-(Dimethylamino)ethanol | HCID 7902 | — |
| 반응물 | Triphenylphosphine | HCID 11776 | — |
| 반응물 | ethyl N-ethoxycarbonyliminocarbamate | HCID 220568 | — |
| 반응물 | 6-Hydroxy-3,4-dihydro-1(2H)-naphthalenone | HCID 4679494 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 6-(2-Dimethylaminoethoxy)-1-tetralone | HCID 12214387 | — |
반응 단계
To a mixture of 6-hydroxy-1-tetralone (Aldrich, 1.0 g, 6.17 mmol, 1.0 eq), N,N-dimethylethanolamine (Aldrich, 0.93 mL, 9.26 mmol, 1.5 eq), and triphenylphosphine (Aldrich, 2.43 g, 9.26 mmol, 1.5 eq) in THF (10 mL) was added diethyl azodicarboxylate (Aldrich, 1.94 mL, 12.34 mmol, 2.0 eq) at 0° C. The reaction mixture was gradually warmed to RT and continued to stir overnight. The solvent was evaporated in vacuo. The residue was purified by silica gel chromatography (3%-5% MeOH—CH2Cl2) to provide the product as orange oil. MS (ESI): 234 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07425631B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-30652c6c4f424175b90fd002eef49a3c |
| 출처 메모 | uspto-grants-2008_09 |