Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic Anhydride → 5-Acetamido-phthalide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic Anhydride | HCID 7918 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | 5-Aminophthalide | HCID 720669 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 5-Acetamido-phthalide | HCID 590968 | 97.1% |
반응 단계
In tetrahydrofuran (100 ml) was dissolved 5-aminophthalide (10 g, 67.05 mmol), and triethylamine (18.64 ml, 134 mmol) was added thereto. To the resulting mixture was added dropwise acetic anhydride (12.61 ml, 134 mmol) under ice-cooling, followed by stirring at room temperature for 3 hours. After addition of a 5% aqueous solution of sodium hydrogen carbonate, the precipitated white solid was separated by filtration, washed several times with water, and then dried to give 5-acetamidophthalide (12.45 g, 97%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06211227B1 |
| 출처 데이터셋 | uspto-grants-2001_04 |
| ORD ID | ord-4e7e08e7ad624f8b9f0d0f3875001415 |
| 출처 메모 | uspto-grants-2001_04 |