Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-[4-(3-Hydroxyphenyl)butyl]imidazole → 4-[3-[4-(1-imidazolyl)butyl]phenoxymethyl]-2-[(E)-2-phenylethenyl]oxazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-[4-(3-Hydroxyphenyl)butyl]imidazole | HCID 22009661 | — |
| 반응물 | 4-Chloromethyl-2-styryl-oxazole | HCID 22009752 | — |
| 생성물 | 4-[3-[4-(1-imidazolyl)butyl]phenoxymethyl]-2-[(E)-2-phenylethenyl]oxazole | HCID 22009776 | 70% |
반응 단계
In substantially the same manner as in Working Example 72, 1-[4-(3-hydroxyphenyl)butyl]imidazole was allowed to react with 4-chloromethyl-2-[(E)-2-phenylethenyl]oxazole to give 4-[3-[4-(1-imidazolyl)butyl]phenoxymethyl]-2-[(E)-2-phenylethenyl]oxazole. The yield was 70%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 75-76° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06211215B1 |
| 출처 데이터셋 | uspto-grants-2001_04 |
| ORD ID | ord-6c27999ea8ac42c58ec3af0bc12bf1c2 |
| 출처 메모 | uspto-grants-2001_04 |