Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Nitroacetamide → 6-Cyclopropyl-3-nitropyridin-2-ol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Nitroacetamide | HCID 279256 | — |
| 반응물 | Piperidinium acetate | HCID 3014295 | — |
| 반응물 | 1-Cyclopropyl-3-(dimethylamino)prop-2-en-1-one | HCID 7017677 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 6-Cyclopropyl-3-nitropyridin-2-ol | HCID 22008779 | — |
반응 단계
A mixture of crude β-N,N-dimethylaminoethenylcyclopropyl ketone (17-2; 12 g, <86 mmol), nitroacetamide (9 g, 86 mmol) and aqueous piperidinium acetate (10 ml) [prepared from glacial acetic acid (42 ml), water (100 ml) and piperidine (72 ml)] was stirred at room temperature overnight. Following dilution with water (20 ml), the yellow precipitate was isolated via filtration and drying in vacuo to yield the title compound 17-3: 1H NMR (CDCl3) δ 1.15 (m, 2H), 1.36 (m, 2H), 2.10 (m, 1H), 6.02 (br d, J=8.0 Hz, 1H), 8.41 (d, J=8.0 Hz, 1H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06211184B1 |
| 출처 데이터셋 | uspto-grants-2001_04 |
| ORD ID | ord-94baea0836ba4ff38a624998dff13d06 |
| 출처 메모 | uspto-grants-2001_04 |