Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethanol → 4-Amino-N-[2-(diethylamino)ethyl]-2-methoxybenzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethanol | HCID 702 | — |
| 반응물 | 4-nitro-N-(2-diethylamino-ethyl)-2-methoxy-benzamide | HCID 408891 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 4-Amino-N-[2-(diethylamino)ethyl]-2-methoxybenzamide | HCID 77374 | 106.4% |
반응 단계
5.7 g (19.3 mmol) of 4-nitro-N-(2-diethylamino-ethyl)-2-methoxy-benzamide is dissolved in 120 ml of tetrahydrofuran:ethanol=1:1, mixed with 2 g of palladium on carbon (10%×50% water) and hydrogenated for 1 hour at room temperature and normal pressure. After being drawn off on diatomaceous earth and after concentration by evaporation, 5.45 g of 4-amino-N-(2-diethylamino-ethyl)-2-methoxy-benzamide is obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07427390B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-a4a84b761f37465986edb7e193759a3c |
| 출처 메모 | uspto-grants-2008_09 |