Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-benzyl-2-(chloromethyl)-1H-imidazole hydrochloride → 1-(3,4,5-trimethoxybenzoyl)-3-(2-(4-(1-(1-benzyl-1H-imidazol-2-ylmethyl)-1H-benzimidazol-2-yl-amino)piperidin-1-yl)ethyl)-3-(3,4-difluorophenyl) pyrrolidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-benzyl-2-(chloromethyl)-1H-imidazole hydrochloride | HCID 2779243 | — |
| 반응물 | 1-(3,4,5-trimethoxybenzoyl)-3-(2-(4-(1H-benzimidazol-2-yl-amino)piperidin-1-yl)ethyl)-3-(3,4-difluorophenyl)pyrrolidine | HCID 22009216 | — |
| 생성물 | 1-(3,4,5-trimethoxybenzoyl)-3-(2-(4-(1-(1-benzyl-1H-imidazol-2-ylmethyl)-1H-benzimidazol-2-yl-amino)piperidin-1-yl)ethyl)-3-(3,4-difluorophenyl) pyrrolidine | HCID 69955259 | — |
반응 단계
Prepare by the method of Example 37.2 using 1-(3,4,5-trimethoxybenzoyl)-3-(2-(4-(1H-benzimidazol-2-yl-amino)piperidin-1-yl)ethyl)-3-(3,4-difluorophenyl) pyrrolidine (5 mmol) and 1-benzyl-1H-imidazol-2-ylmethylchloride hydrochloride to give the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06211199B1 |
| 출처 데이터셋 | uspto-grants-2001_04 |
| ORD ID | ord-8e8e17a6addf456a90ae9cdb81462569 |
| 출처 메모 | uspto-grants-2001_04 |