Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Methylmorpholine → Boc-Leu-Glu-OtBu
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Methylmorpholine | HCID 7972 | — |
| 반응물 | 1-(1,1-Dimethylethyl) hydrogen L-glutamate | HCID 117505 | — |
| 반응물 | Boc-Leu-OSu | HCID 11023929 | — |
| 촉매 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | Boc-Leu-Glu-OtBu | HCID 87984260 | — |
반응 단계
To a solution of Boc-Leu-OSu and Glu-OtBu in DMF was added NMM and DMAP. The solution was stirred at ambient temperatures for 18 hours then the solvent was removed. Crude product was taken up in 100 ml CHCl3, washed 3× with pH 3 water (100 ml), once with water (100 ml) and once with brine (100 ml). Organic layer was dried with MgSO4 and filtered. Solvent was removed and solid was dried over vacuum. Solid was collected as a white powder (8.78 g, quant. yield, ˜80% purity TLC). Product was used directly without further characterization.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07427600B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-a4465bcbca00476b927678186da410d5 |
| 출처 메모 | uspto-grants-2008_09 |