Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl 2-(bromomethyl)-1,3-oxazole-4-carboxylate → (+/-)-2-[[5-(2-Ethyl-7-methyl-4H-benzo[5,6]cyclohepta[1,2-d]oxazol-4-yl)-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-4-oxazolecarboxylic acid, ethyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl 2-(bromomethyl)-1,3-oxazole-4-carboxylate | HCID 641223 | — |
| 반응물 | (+/-)-5-(2-Ethyl-7-methyl-4H-benzo[5,6]cyclohepta[1,2-d]oxazol-4-yl)-2,4(1H,3H)-pyrimidinedione | HCID 70112980 | — |
| 생성물 | (+/-)-2-[[5-(2-Ethyl-7-methyl-4H-benzo[5,6]cyclohepta[1,2-d]oxazol-4-yl)-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-4-oxazolecarboxylic acid, ethyl ester | HCID 131722501 | — |
반응 단계
The subtitle compound was prepared from the product from example 1 step (vii) (6.5 g) and 2-[bromomethyl]-4-oxazolecarboxylic acid ethyl ester (Coll. Czech Chem. Comm., 1967, 32, 2155) (1.69 g) by the method of example 1 step (viii). Purification was by chromatography eluting with 60-66% ethyl acetate in toluene.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06218376B1 |
| 출처 데이터셋 | uspto-grants-2001_04 |
| ORD ID | ord-b60c5104cf494f52bcd926f4682ea92e |
| 출처 메모 | uspto-grants-2001_04 |