Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 324484생성일: 2026년 10월 24일
Methanol → (+/-)-5-(7-Chloro-1,2-dimethyl-4H-benzo[5,6]cyclohepta[1,2-d]imidazol-4-yl)-1-methyl-2,4(1H,3H)-pyrimidinedione
https://huagongshe.com/ko/reaction/324484
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Boron trifluoride etherate | HCID 8000 | — |
| 반응물 | 1-Methyluracil | HCID 12009 | — |
| 반응물 | (+/-)-7-Chloro-1,2-dimethyl-4H-benzo[5,6]cyclohepta[1,2-d]imidazol-4-ol | HCID 22003588 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | (+/-)-5-(7-Chloro-1,2-dimethyl-4H-benzo[5,6]cyclohepta[1,2-d]imidazol-4-yl)-1-methyl-2,4(1H,3H)-pyrimidinedione | HCID 22003604 | — |
반응 단계
A mixture of the product from step (iii) (0.91 g), and 1-methyluracil (0.44 g) in acetonitrile (40 ml) was treated with boron trifluoride etherate (2.47 g) and heated at 50° C. for 4 h. The solution was treated with methanol (1 ml) and evaporated. Purification was by chromatography on a biotage silica column, using 3% methanol/0.1% 0.880 ammonia in dichloromethane as eluant to give the subtitled product as a cream powder.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US06218376B1 |
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| 출처 데이터셋 | uspto-grants-2001_04 |
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| ORD ID | ord-24895a3d2b4044ac8a8aafa6ec8d6d06 |
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| 출처 메모 | uspto-grants-2001_04 |
|---|
