Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diisopropylethylamine → 2-[4-(5-Bromo-2-methoxybenzyl)-1-piperazinyl]pyrimidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 4-Bromo-2-(chloromethyl)-1-methoxybenzene | HCID 10354068 | — |
| 반응물 | 2-Piperazinylpyrimidine dihydrochloride | HCID 11680272 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 생성물 | 2-[4-(5-Bromo-2-methoxybenzyl)-1-piperazinyl]pyrimidine | HCID 1240303 | 235% |
반응 단계
A mixture of 1.1 g of 2-(chloromethyl)-4-bromoanisole, 1 g of 1-(2-pyrimidyl)piperazine dihydrochloride and 2.0 mL N,N-diisopropylethylamine in 10 mL chloroform was heated at reflux temperature for 2 hr, cooled to room temperature, washed with 1 N NaOH and water. The solvent was removed by evaporation under reduced pressure to yield 3.6 g of 2-[(4-(2-pyrimidinyl)-piperazinyl)methyl]-4-bromoanisole as a white solid which was used in the next step without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06221871B1 |
| 출처 데이터셋 | uspto-grants-2001_04 |
| ORD ID | ord-a6541a6b4c3c406ba75045da9a273aa6 |
| 출처 메모 | uspto-grants-2001_04 |