Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Fluoro-5-(trifluoromethyl)phenyl isocyanate → N-{4-[5-(4-Aminothieno[2,3-d]pyrimidin-6-yl)-1-methyl-1H-imidazol-4-yl]phenyl}-N'-[2-fluoro-5-(trifluoromethyl)phenyl]urea
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Fluoro-5-(trifluoromethyl)phenyl isocyanate | HCID 2733380 | — |
| 반응물 | 6-[4-(3-aminophenyl)-1-methyl-1H-imidazol-5-yl]thieno[2,3-d]pyrimidin-4-amine | HCID 69054399 | — |
| 반응물 | 6-[4-(4-Aminophenyl)-1-methyl-1H-imidazol-5-yl]thieno[2,3-d]pyrimidin-4-amine | HCID 69197158 | — |
| 생성물 | N-{4-[5-(4-Aminothieno[2,3-d]pyrimidin-6-yl)-1-methyl-1H-imidazol-4-yl]phenyl}-N'-[2-fluoro-5-(trifluoromethyl)phenyl]urea | HCID 10482015 | — |
반응 단계
The title compound was prepared by a similar process to that described for Example 186 but using 6-[4-(4-aminophenyl)-1-methyl-1H-imidazol-5-yl]thieno[2,3-d]pyrimidin-4-amine (Intermediate 112) in place of 6-[4-(3-aminophenyl)-1-methyl-1H-imidazol-5-yl]thieno[2,3-d]pyrimidin-4-amine (Intermediate 110) and using 2-fluoro-5-trifluoromethylphenyl isocyanate in place of phenyl isocyanate. Colourless solid (48 mg, 73%);
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07427616B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-6b13e9bf308a4f08abc80bd2fe1a9029 |
| 출처 메모 | uspto-grants-2008_09 |