Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → Coumate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Chlorosulfamic acid | HCID 24499 | — |
| 반응물 | 4-Methylumbelliferone | HCID 5280567 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | Coumate | HCID 9859866 | 41.1% |
반응 단계
A slurry of 7-hydroxy-4-methylcoumarin (17.6 g, 0.10 mole) in acetonitrile (100 ml) was treated with a total of 84 ml of 3M sulfamoyl chloride (0.255 mole) in acetonitrile. The mixture was then treated dropwise with triethylamine (25.8 g, 0.255 mole). The reaction temperature was allowed to rise to 45° without any cooling. The mixture was stirred overnight at ambient temperature. The precipitate was collected, triturated with water, and dried in a vacuum oven at 70° C. for 15 hr to give 10.5 g (41%) of white powder, mp 161°-164° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05273993 |
| 출처 데이터셋 | uspto-grants-1993_12 |
| ORD ID | ord-716ec8270da347688c7babe111970277 |
| 출처 메모 | uspto-grants-1993_12 |