Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethylamine hydrochloride → N-Ethyl-2-(4-iodo-phenyl)-propionamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethylamine hydrochloride | HCID 11198 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 반응물 | 2-(4-Iodophenyl)propanoic acid | HCID 15225573 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | N-Ethyl-2-(4-iodo-phenyl)-propionamide | HCID 66693450 | — |
반응 단계
1.97 g (7.14 mmol) 2-(4-Iodo-phenyl)-propionic acid (111.1) and 1.25 mL (7.14 mmol) DIPEA are added to 582 mg (7.14 mmol) ethylamine hydrochlorid in 70 mL DCM. 1.64 g (8.57 mmol) N-(3-Dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride and 194 mg (1.43 mmol) 1-hydroxy-7-azabenotriazole are added at 0° C. Subsequently, cooling is removed and the mixture is stirred for 20 h at rt. After that time, the mixture is washed with water and brine, dried over sodium sulphate and the solvent is evaporated. The residue is purified by column chromatography (silicia gel; heptane:EtOAc 50:50).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08877754B2 |
| 출처 데이터셋 | uspto-grants-2014_11 |
| ORD ID | ord-a3e0281aa7624959a4a5400401d16364 |
| 출처 메모 | uspto-grants-2014_11 |