Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl 6-chloro-4-(trifluoromethyl)nicotinate → 6-(5-Methyl-3-phenyl-isoxazol-4-ylmethoxy)-4-trifluoromethyl-nicotinic acid methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl 6-chloro-4-(trifluoromethyl)nicotinate | HCID 2775340 | — |
| 반응물 | (5-Methyl-3-phenyl-1,2-oxazol-4-yl)methanol | HCID 2776149 | — |
| 생성물 | 6-(5-Methyl-3-phenyl-isoxazol-4-ylmethoxy)-4-trifluoromethyl-nicotinic acid methyl ester | HCID 68444933 | — |
반응 단계
As described for example 5, (5-methyl-3-phenyl-isoxazol-4-yl)-methanol (3.47 g, 18.4 mmol) was converted using methyl 6-chloro-4-(trifluoromethyl)nicotinate instead of 6-chloronicotinonitrile to the title compound which was used directly in the next transformation without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08877783B2 |
| 출처 데이터셋 | uspto-grants-2014_11 |
| ORD ID | ord-f37680c7e99d42f6b9f1425285a2989d |
| 출처 메모 | uspto-grants-2014_11 |